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    Ingredient Profile

    Methyl Anthranilate fragrance note

    Bright, grape‑like aroma with a hint of strawberry, methyl anthranilate bridges fruit and floral worlds, delivering a crisp, sweet note that…More

    United States

    1

    Fragrances

    Fragrances featuring Methyl Anthranilate

    Character

    The Story of Methyl Anthranilate

    Bright, grape‑like aroma with a hint of strawberry, methyl anthranilate bridges fruit and floral worlds, delivering a crisp, sweet note that instantly recalls ripe vineyard clusters.

    Heritage

    The story of methyl anthranilate begins in the early twentieth century, when flavor houses sought a stable substitute for fresh berries. In 1923 a Cincinnati firm, Alex Fries & Brothers, reported a successful synthesis that reproduced strawberry and pineapple notes for confectionery. By the 1950s the compound’s grape‑like character caught the attention of perfumers, who adopted it to create the iconic artificial grape scent in both cosmetics and fine fragrance. Its sharp, sweet profile filled a market gap left by scarce natural grape extracts, leading to widespread use in candy, beverages, and scented products throughout the 1970s and 1980s. The 1990s saw the first large‑scale fragrance applications, with major houses listing methyl anthranilate in top‑note accords of fruity and gourmand creations. In 2005, gas‑chromatography‑olfactometry confirmed its dominance, ranking it as the primary grape odorant among synthetic esters. The 2010s introduced microbial production, allowing the molecule to be generated from sugar without petrochemicals, a milestone celebrated at the 2018 International Fragrance Symposium. Today, methyl anthranilate remains a benchmark for grape aroma, linking a century of innovation from early flavor labs to contemporary sustainable chemistry.

    At a Glance

    Fragrances

    1

    Feature this note

    Origin

    United States

    Primary source region

    Ingredient Details

    Extraction

    Synthetic

    Used Parts

    Anthranilic acid (synthetic precursor) and methanol

    Did You Know

    "Although first synthesized in the 1920s to mimic strawberry flavor, methyl anthranilate became the signature scent of artificial grape candies and now powers modern perfumery."

    Production

    How Methyl Anthranilate Is Made

    Industrial production of methyl anthranilate relies on a straightforward esterification. Manufacturers combine anthranilic acid, a petroleum-derived aromatic acid, with methanol in the presence of sulfuric acid catalyst. The mixture is heated to 80–100 °C, allowing the acid and alcohol to form the ester and water. After reaction completion, the crude product undergoes neutralization, then vacuum distillation to remove residual acids and solvents. The final distillate is a clear, colorless liquid with a characteristic grape odor. Modern plants integrate continuous reactors, achieving conversion rates above 95 % and product purities of 98 % or higher. Waste streams are treated with alkaline scrubbers to meet environmental regulations. Since the 2010s, biotech firms have introduced microbial fermentation routes, engineering yeast to convert glucose into methyl anthranilate via the shikimate pathway. Fermentation batches yield up to 1.2 g per liter, offering a renewable alternative that reduces reliance on petrochemical feedstocks while maintaining fragrance quality.

    Provenance

    United States

    United States39.0°N, 95.0°W

    About Methyl Anthranilate